EPICARE ECG Reading Center

A Leader in Population Electrocardiography

EPICARE's mission is rooted in scientific excellence, innovation, collaboration, and a commitment to making significant contributions to cardiovascular epidemiology and population electrocardiography.

Our core objectives align with conducting cutting-edge research, promoting evidence-based practices, and collaborating with the global scientific community to make a positive impact on cardiovascular health.

Key elements of our mission include:
✔ Research Excellence
✔ Innovative Technologies
✔ Collaboration and Partnerships
✔ Knowledge Translation

Services

ECG data processing and analysis

Standardization and quality control of ECG recording

Data integration with other research investigative tools

Advanced analytical approaches and artificial intelligence such as deep & machine learning

Training and certification of ECG technicians

Monitoring and reporting ECG alerts in population studies

Equipment & Software

GE MUSE NX Cardiology System

Microsoft SQL Server Enterprise

EPICARE classification program

MATLAB

Python

SAS

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ECG Coding

Classification systems used in EPICARE.
Minnesota codes | Nova codes

Studies

EPICARE has been the ECG Reading Core for the largest and best-known clinical trials and epidemiologic studies.

Study logos

Examples of current and past studies

AADHS

African American Diabetes Heart Study

ACCORD

Action to Control Cardiovascular Disease in Diabetics Study

ACCORDION

Action to Control Cardiovascular Disease in Diabetics Study, Follow-up

ARCADIA

AtRial Cardiopathy and Antithrombotic Drugs In Prevention After Cryptogenic Stroke.

ARIC

Atherosclerosis Risk in Communities Study.

ASSESS/AKI

Assessment, Serial Evaluation & Subsequent Sequelae in Acute Kidney Injury

Bogalusa

Bogalusa Heart Study

CACTI

Coronary Artery Calcification in Type 1 Diabetes

CAMACS

The Multicenter AIDS Cohort Study

CARDIA

Coronary Artery Risk Development in Young Adults

CHAGAS

Genetic Aspects of Seropositivity for Chagas Disease

CHAP

Chicago Health and Aging Project

CHAS

Chicago Healthy Aging Study

CHS

Cardiovascular Health Study

CREST

Carotid Revascularization Endarterectomy vs. Stent Trial

CRIC

Chronic Renal Insufficiency Cohort Study

DHS

Diabetes Heart Study

DPPOS & DPP

Diabetes Prevention Program Outcomes Study.

EDIC

Epidemiology of Diabetes Intervention and Complications Study.

GRADE

Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study.

HCHS

Hispanic Community Health Study

Healthy Aging

Northwestern University Healthy Aging Study

Insight START

International Network for Stategic Initiatives in Global HIV Trials

IRAS

Insulin Resistance Atherosclerosis Study

JHS

Jackson Heart Study.

LOOKAHEAD

Action for Health in Diabetes Trial

MESA

MESA Atrial Fibrillation Study

MRFIT

Multiple Risk Factor Intervention Trial

NHANES

National Health and Nutrition Examination Survey

REDS

Chagas Disease Study (Westat)

REGARDS

Reasons for Geographic and Racial Differences in Stroke Study

RURAL

Risk Underlying Rural Areas Longitudinal Study.

SMART

Strategies for Management if Anti-Retroviral Therapy

SPRINT

Systolic Blood Pressure Intervention Trial

St. Jude

St. Jude's Follow-up

TOMHS

Treatment of Mild Hypertension Study

WHI

Women's Health Initiative Study

WIHS

Women's Interagency HIV Study

👉 For other studies click here.

EPICARE Team

EPICARE ECG reading center team

Interns & Scholars

Our History

The origins of the EPICARE Center can be traced back to Dalhousie University, where it functioned for over a quarter of a century under the name of the Heart Disease Research Center. The Center was formed with the support of the Nova Scotia Heart Foundation, and the Dalhousie University Medical School.

In 1990 the Center moved to Edmonton Alberta and was renamed the EPICORE Center. The Alberta Heritage Foundation for Medical Research, the Heart and Stroke Foundation of Alberta, the University of Alberta, and the University of Alberta Hospital supported the evolving center.

The Center found its final resting place at Wake Forest University Medical School, in Winston Salem, North Carolina, and was renamed the EPICARE Center. The center continues the role as an international resource for national health surveys, epidemiological studies and multicenter clinical trials in computer analysis and classification of resting, exercise and ambulatory electrocardiograms.

Through its experience and expertise in ECG analysis, the Center plays a vital role in many aspects of clinical trials, such as the establishment of the incidence of non-fatal endpoints, monitoring trends between treatment groups, detection of adverse effects of cardioactive drugs, and comparative assessment of trends in cardiovascular disease morbidity between contrasting populations. The research arm of the EPICARE Center conducts a broad spectrum of basic and applied research in Electrocardiology dedicated to investigate the evolution of the cardiac excitation and repolarization processes both through the normal lifetime and aging, and through aberrations during various disease conditions.